The Impact of Preoperative Opioid Use Disorder on Complications and Costs following Primary Total Hip and Knee Arthroplasty

Table 3

Multivariate analysis of healthcare utilization-associated factors.

Complication		Nonopioid dependent^a	Opioid dependent^a	Beta coefficient or odds ratio^b	value (multivariate)
TKA	Nonhome discharge	621,157 (27.9%)	1,729 (31.0%)	1.47 (1.30–1.64)	<0.001
	90-day readmission	190,769 (8.6%)	823 (14.8%)	1.60 (1.43–1.79)	<0.001
	Length of stay (days)	3.43 ± 2.74	4.39 ± 4.22	+0.67 days (0.56–0.78)	<0.001
	Inpatient cost (USD)	$17,013 ± 8,923	$20,394 ± 11,067	+$2,522 (2,170–2,874)	<0.001
	Total 90-day cost (USD)	$18,250 ± 11,575	$22,873 ± 15,793	+$3,602 (3,138–4,065)	<0.001
THA	Nonhome discharge	327,408 (27.3%)	1,357 (31.9%)	1.40 (1.28–1.53)	<0.001
	90-day readmission	112,624 (9.4%)	777 (18.2%)	1.53 (1.43–1.79)	<0.001
	Length of stay (days)	3.48 ± 3.59	5.26 ± 9.40	+1.09 days (0.95–1.24)	<0.001
	Inpatient cost (USD)	$17,943 ± 9,799	$22,307 ± 15,385	+$2,924 (2,496–3,353)	<0.001
	Total 90-day cost (USD)	$19,603 ± 13,252	$26,198 ± 21,360	+$4,257 (3,593–4,920)	<0.001

^aPresented as mean ± standard deviation for continuous variables or n (%) for categorical variables, and univariate values represent unmatched cohorts. ^bOdds ratio or beta coefficient with 95% confidence interval obtained through multivariate regression on matched cohorts while controlling for patient and operative characteristics; beta represents an increase in days and dollars associated with an opioid use disorder.