Table of Contents
Advances in Orthopedic Surgery
Volume 2015, Article ID 257925, 5 pages
Research Article

Elution Characteristics of Vancomycin, Gentamicin, and Vancomycin/Gentamicin Combination from Calcium Phosphate Cement

1Department of Orthopaedic Surgery, Kitasato University Medical Center, 6-100 Arai, Kitamoto, Saitama 364-8501, Japan
2HOYA Technosurgical Corporation, 1-1-110 Tsutsujigaoka, Akishima, Tokyo 196-0012, Japan
3Department of Orthopaedic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0375, Japan

Received 11 February 2015; Revised 6 May 2015; Accepted 6 May 2015

Academic Editor: Werner Kolb

Copyright © 2015 Masataka Uchino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The antibiotic elution profiles from calcium phosphate cement (CPC) used for treating infection sites after total joint arthroplasty vary depending on the type and number of impregnated antibiotics. The purpose of this study was to develop a method for efficiently eluting vancomycin hydrochloride (VCM) and gentamicin sulfate (GM) from CPC. Examination of the antibiotic elution profiles of CPC impregnated with either VCM (CPC/V) or GM (CPC/G) or both (CPC/VG) revealed that the early elution of VCM from CPC/VG was impaired compared to CPC/V. However, the elution of GM from CPC/VG was similar or higher compared to CPC/G. Scanning electron microscopy showed that the pore structure of CPC markedly differed depending on the type and number of antibiotics present. The pore size of CPC/VG was smaller compared to CPC/V but was larger compared to CPC/G. Thus, the inhibition of the early elution of VCM, which is a larger molecule than GM, was attributed to the decreased pore size of CPC/VG. These findings suggest that when dual treatment with VCM and GM is required for infection following total joint arthroplasty, each antibiotic should be individually impregnated into CPC to maximize the elution efficiency of VCM.