Table of Contents
Advances in Pharmaceutics
Volume 2014, Article ID 304392, 6 pages
http://dx.doi.org/10.1155/2014/304392
Research Article

Pharmacodynamics and Pharmacokinetics Evaluation of Ranitidine Microemulsion on Experimental Animals

1Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences & Research, BRB Sarani, Bidhannagar, Durgapur, West Bengal 713212, India
2Department of Industrial Pharmacy, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Bangalore, Karnataka 560090, India

Received 18 July 2014; Revised 29 August 2014; Accepted 2 October 2014; Published 20 October 2014

Academic Editor: Maria Cristina Bonferoni

Copyright © 2014 Sajal Kumar Jha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ranitidine microemulsion was investigated for its pharmacodynamic and pharmacokinetic evaluation to find out the suitability of microemulsion as a potential drug delivery system in the treatment of ulcer. The bioavailability of ranitidine after oral administration is about 50% and is absorbed via the small intestine; this may be due to low intestinal permeability. Hence the aim of present investigation was to maximize the therapeutic efficacy of ranitidine by developing microemulsion to increase the intestinal permeability as well as bioavailability. A ground nut oil based microemulsion formulation with Tween-80 as surfactant and PEG-400 as cosurfactant was developed for oral delivery of ranitidine and characterized for physicochemical parameters. In pharmacodynamic studies, significant () variation in parameters estimated was found between the treated and control groups. Ranitidine microemulsion exhibited higher absorption and Cmax (863.20 ng·h/mL) than the standard (442.20 ng/mL). It was found that AUC0–24 hr obtained from the optimized ranitidine test formulation (5426.5 ng·h/mL) was significantly higher than the standard ranitidine (3920.4 ng·h/mL). The bioavailability of optimized formulation was about 1.4-fold higher than that of standard drug. This enhanced bioavailability of ranitidine microemulsion may be used as an effective and alternative drug delivery system for the antiulcer therapy.