Table of Contents
Advances in Pharmaceutics
Volume 2014, Article ID 439158, 9 pages
http://dx.doi.org/10.1155/2014/439158
Research Article

Rejuvenating of Kidney Tissues on Alloxan Induced Diabetic Mice under the Effect of Momordica charantia

1Department of Biochemistry & Bioprocess Technology, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh 211008, India
2Department of Molecular & Cellular Engineering, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh 211008, India
3PG of Zoology, A.N. College, Patna, Bihar 800013, India
4School of Science, Suresh Gyan Vihar University, Jaipur, Rajasthan 302017, India

Received 2 April 2014; Revised 14 May 2014; Accepted 18 May 2014; Published 15 June 2014

Academic Editor: Hidetaka Akita

Copyright © 2014 Bhaskar Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes mellitus is a chronic disorder in human and responsible for different complications and also causes mortality and morbidity. A wide number of herbal products are employed in the treatment of diabetes for their better efficacy and safety compared to synthetic medicine. The present studies have established the antidiabetic potential and rejuvenating capacity of kidney tissues under the effect of extract. Diabetes was induced in the Swiss albino mice by injecting alloxan at the dose of 150 mg/kg body weight and aqueous extract of Momordica charantia fruits at doses of 100 mg/kg body weight and 250 mg/kg body weight was administered orally for three weeks. After 21 days of treatment of the aqueous extracts of Momordica charantia significantly reduces serum glucose level, kidney function tests, lipid peroxidation as well as histopathological study also did show adverse alternation in the morphological architecture of the kidney tissue. Thus, from this study we concluded that Momordica charantia exhibited significant antihyperglycemic and rejuvenating capacity of kidney tissues activities in alloxan induced diabetic mice.