Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen

Table 6

Permeation parameters for various nanoemulgel formulations.

Formulation code	CADP (mg/cm^2)	Flux	Lag time (h)	Drug retained (mg)
NG1	1.10 ± 0.04	0.057 ± 0.06	2.45 ± 0.21	1.40 ± 0.07
NG2	1.15 ± 0.06	0.058 ± 0.35	1.02 ± 0.16	1.35 ± 0.43
NG3	1.62 ± 0.02	0.072 ± 0.52	0.66 ± 0.26	0.88 ± 0.24
NG4	1.41 ± 0.07	0.064 ± 0.06	3.05 ± 0.23	1.09 ± 0.29
NG5	1.58 ± 0.12	0.066 ± 0.14	1.93 ± 0.18	0.92 ± 0.11
NG6	1.82 ± 0.23	0.074 ± 0.25	0.56 ± 0.64	0.68 ± 0.66
NG7	1.19 ± 0.30	0.057 ± 0.32	2.39 ± 0.18	1.31 ± 0.33
NG8	1.32 ± 0.28	0.059 ± 0.17	2.28 ± 0.11	1.18 ± 0.26
NG9	1.50 ± 0.06	0.063 ± 0.29	0.73 ± 0.28	1.00 ± 0.18
NS1	1.08 ± 0.09^*	0.041 ± 0.32^*	3.68 ± 0.38^*	1.42 ± 0.46^*
NS2	1.11 ± 0.43^*	0.044 ± 0.18^*	3.43 ± 0.42^*	1.39 ± 0.19^*
NS3	1.15 ± 0.42^*	0.045 ± 0.26^*	3.21 ± 0.42^*	1.35 ± 0.25^*

Values are expressed as mean ± SD ().
CADP: cumulative amount of drug permeated.
; Student’s unpaired -test was used to compare NS batch (formulation prepared without cosurfactant) with NG6 (optimized formulation) for CADP, flux, and lag time.