Researches on transfersomes as vesicular drug delivery system.
S. number
Name and year of researchers
Drug
Experiment
Reference
01
Duangjit et al., 2013
Meloxicam (MX)
The aim of this study is to develop Meloxicam- (MX-) loaded cationic transfersomes as skin delivery carriers and to investigate the influence of formulation factors such as cholesterol and cationic surfactants on the physicochemical properties of transfersomes. Transfersomes provided greater MX skin permeation than conventional liposomes and MX suspensions. The skin permeation by the vesicles prepared in this study may be due to the vesicle adsorption to and/or fusion with the stratum corneum.
Transfersomes of Ibuprofen were prepared using various ratios of soya phosphatidylcholine, span 80, and tween 80, using lipid film hydration by rotary evaporation method. The % entrapment efficiency of ibuprofen was 47.8 ± 2.2 and the elasticity of both increases with increase in surfactant conc. and were found to be 34.4 ± 1.4 and 26.5 ± 1.6. Stability studies for transfersomes were carried out for 5 weeks at 45°C. Invitro skin permeation studies were carried by human cadaver skin using franz diffusion cell, and release of the drug and flux was found to be 2.5824 and 1.9672 ug/cm2/hr, respectively, after 24 hrs.
The goal of this study was to develop and evaluate the potential use of liposome and transfersome vesicles in the transdermal drug delivery of Meloxicam (MX). MX-loaded vesicles were prepared and evaluated for particle size, zeta potential, entrapment efficiency (%EE), loading efficiency, in vitro skin permeation study, and stability. The vesicles were spherical in structure, 90 to 140 nm in size, and negatively charged (−23 to −43 mV). The %EE of MX in the vesicles ranged from 40 to 70%. It was concluded that transfersomes provided a significantly higher skin permeation of MX compared to liposomes.
The transfersomes were formulated by modified hand shaking method using surfactant such as Tween 80 and Span 80 in various concentrations. The entrapment efficiency of PC (Lecithin): Edge Activator (Tween 80 and Span 80) ratio dependent was determined. The average vesicle size for the optimized formula was found to be 339.9 nm and the entrapment efficiency was 89.6 ± 0.049.
In the present study transfersomes were prepared by using dexamethasone as a model drug. The stability study was performed at 4°C and 37°C. An in vitro drug release study has shown a nearly zero order release of drug and no lag phase. The absence of lag phase in comparison to liposomes and ointment is attributed to the greater deformability, which may account for better skin permeability of transfersomes. In vivo studies of transfersomes showed better antiedema activity in comparison to liposomes and ointment, indicating better permeation through the penetration barrier of the skin.
