Lipid Based Vesicular Drug Delivery Systems

Table 4

Researches on aquasomes as vesicular drug delivery system.

S. number	Name and year of researchers	Drug	Experiment	Reference
01	Nanjwade et al., 2013	Etoposide	Etoposide aquasomes were obtained through the formation of an inorganic core of calcium phosphate covered with; a lactose film and further adsorption of the Etoposide. The diameter of drug loaded aquasomes was found to be in the range of 150 to 250 nm. Entrapment efficiency was found to be 88.41%. The average targeting efficiency of drug loaded nanoparticles was found to be 42.54% of the injected dose in liver, 12.22% in lungs, 4.14% in kidney, and 25.12% in spleen. The results discovered that the nanoparticles bearing drug showed better drug targeting to liver followed by spleen, lungs, and kidney. Stability studies indicated that 4°C is the most suitable temperature for storage of Etoposide nanoparticles.	[40]
02	Vengala et al., 2013	Piroxicam	Ceramic nanoparticles of poorly aqueous soluble Piroxicam were prepared to explore the relationship between particle size and dissolution profile. The percent yield of ceramic nanoparticles was 66.7%. The dissolution profile of piroxicam aquasomes was obtained in 0.1 mol/L hydrochloric acid solution. The release of piroxicam from ceramic nanoparticles was linear and exhibited zero order kinetics. It was observed that the piroxicam ceramic nanoparticle formulations elicited release of piroxicam in 1 h and 15 min.	[41]
03	Tiwari et al., 2012	Dithranol	Aquasomes were prepared using colloidal precipitation method and then dispersed into a cream for the treatment of psoriasis. The drug loading efficiency was found to be 84.8% w/w. 55.93% drug release was observed in 7 hours. In in vitro drug release studies from both the creams revealed that aquasome loaded cream controlled the drug release as compared to plain cream.	[42]
04	Kommineni et al., 2012	Insulin	Insulin bearing aquasomes were prepared by the standard method employed for the preparation of aquasomes. The prepared systems were characterized for size, shape, size distribution, drug loading efficiency, and in vivo performance. The in vivo performance of the formulated aquasome was compared with standard porcine insulin solution, and better results were observed compared to insulin solution.	[43]
05	Cherian et al., 2000	Piroxicam	Ceramic nanoparticles were prepared using two techniques, namely, coprecipitation by refluxing and coprecipitation by sonication. Core preparation was finally done using sonication approach, based on the higher % yield (42.4  ±  0.4%) and shorter duration (1 day) compared to the reflux method (27.4  ±  2.05%, 6 days). Morphological evaluation revealed spherical nanoparticles (size 56.56  ±  5.93 nm for lactose coated core and 184.75  ±  13.78 nm for piroxicam loaded aquasomes) confirming the nanometric dimensions.	[44]