Enhanced Degradation of Lactide-co-Glycolide Polymer with Basic Nucleophilic Drugs

Table 2

Rate constant and half-life for Placebo, Olanzapine, and Risperidone microspheres.

	% drug loading
Parameter measured	0	1		5		10		15		35
	Placebo	Risp.	Olanz.	Risp.	Olanz.	Risp.	Olanz.	Risp.	Olanz.	Risp.
or (day^−1)	0.003	0.148	0.047	0.141	0.077	0.184	0.083	0.359	0.080	0.306
or (day)	213	4.68	14.6	4.91	8.97	3.77	8.35	1.93	8.63	2.267
(day^−1)	—	0.007	—	0.014	—	0.014	—	0.060	—	0.053
(day)	—	102.3	—	48.1	—	49.5	—	11.5	—	13.2