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Advances in Pharmaceutics

Advances in Pharmaceutics / 2015 / Article / Tab 2

Research Article

Enhanced Degradation of Lactide-co-Glycolide Polymer with Basic Nucleophilic Drugs

Table 2

Rate constant and half-life for Placebo, Olanzapine, and Risperidone microspheres.
 % drug loading
Parameter measured015101535
 PlaceboRisp.Olanz.Risp.Olanz.Risp.Olanz.Risp.Olanz.Risp.
or (day−1)0.0030.1480.0470.1410.0770.1840.0830.3590.0800.306
or (day)2134.6814.64.918.973.778.351.938.632.267
(day−1)—0.007—0.014—0.014—0.060—0.053
(day)—102.3—48.1—49.5—11.5—13.2