Acute and Subchronic Toxicity Profile of Euphorbia pulcherrima Methanol Extract on Wistar Albino Rats

Table 2

Effect of the E. pulcherrima extract on the serum urea, creatinine, and electrolytes level (kidney function parameters) of rats.

Kidney parameters; (reference values)	Group A; (1000 mg/Kg)	Group B; (100 mg/Kg)	Group C; (10 mg/Kg)	Group D; (Control)
Na^+ (Mol/L); (135–150)	129.8 ± 0.38	133.8 ± 2.44	132.6 ± 1.64	132.8 ± 2.39
K^+ (Mol/L); (3.4–5.3)	3.58 ± 0.09	3.8 ± 0.56	3.8 ± 0.77	3.7 ± 0.56
Cl^− (mMol/L); (95–110)	85.8 ± 0.66	93.2 ± 3.35	91.6 ± 2.75	91.8 ± 2.94
(Mol/L); (24–32)	25.8 ± 0.66	25.8 ± 1.34	25.6 ± 1.35	26.6 ± 1.16
Creatinine (mMol/L); (90–126)	70.4 ± 5.57	69.4 ± 1.75	87.6 ± 3.81	86.6 ± 3.0
Urea (mMol/L); (2.5–6.5)	5.38 ± 0.58	5.6 ± 0.95	7.86 ± 1.14	7.92 ± 1.19

Values are expressed as mean ± SEM for = 5. Values are considered significant if ().