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Research Letters in Physical Chemistry
Volume 2007 (2007), Article ID 82901, 5 pages
Research Letter

Kinetics and Mechanism of Paracetamol Oxidation by Chromium(VI) in Absence and Presence of Manganese(II) and Sodiumdodecyl Sulphate

1Department of Chemistry, Jamia Millia Islamia, Central University, Jamia Nagar, New Delhi 110025, India
2Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

Received 24 May 2007; Accepted 6 August 2007

Academic Editor: Vasudevanpillai Biju

Copyright © 2007 Mohammed Ilyas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The kinetics of paracetamol oxidation are first order each in [paracetamol] and [HClO4]. The kinetic study shows that the oxidation proceeds in two steps. The effects of anionic micelles of sodiumdodecyl sulphate (SDS) and complexing agents (ethylenediammine tetraacetic acid (EDTA) and 2,2-bipyridyl (bpy)) were also studied. Fast kinetic spectrophotometric method has been described for the determination of paracetamol. The method is based on the catalytic effect of manganese(II) on the oxidation of paracetamol by chromium(VI) in the presence of HClO4 (= 0.23 mol dm3). Optimum reaction time is 4 to 6 minutes at a temperature of 30C. The addition of manganese(II) ions largely decreased the absorbance of chromium(VI) at 350 nm. This reaction can be utilized for the determination of paracetamol in drugs.