The Cold Contact Method as a Simple Drug Interaction Detection System
Figure 1
(a) The cold contact area of acetaminophen-pseudoephedrine HCl
corecrystallization showed an area which melted at (1) 113ºC, compared to the starting
materials at (2) 170ºC and (3) 184ºC. (b)
Thermograms of pseudoephedrine HCl showed melting
point at 184.4ºC (top), acetaminophen at 169.5ºC (middle), and the
eutectic mixture in weight ratios 5 : 5 at 112.3ºC
(bottom).