Research Letter

The Cold Contact Method as a Simple Drug Interaction Detection System

Figure 1

(a) The cold contact area of acetaminophen-pseudoephedrine HCl corecrystallization showed an area which melted at (1) 113ºC, compared to the starting materials at (2) 170ºC and (3) 184ºC. (b) Thermograms of pseudoephedrine HCl showed melting point at 184.4ºC (top), acetaminophen at 169.5ºC (middle), and the eutectic mixture in weight ratios 5 : 5 at 112.3ºC (bottom).
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