Investigation of Antileishmanial Activities of Acridines Derivatives against Promastigotes and Amastigotes Form of Parasites Using Quantitative Structure Activity Relationship Analysis

Table 8

Values of descriptors, antileishmanial activity pIC₅₀, and leverages () for the new designed compounds.

Designed compounds	Number	Descriptors values	pIC50 (PRO)	Number	Descriptors values	pIC50 (AMA)
		R1 = OH; R2 = CH3; N% = 12.490; = 2.232; = 3.099; NHA = 3; NHD = 2; MTI = 3651; TVC = 3.34 10^−05	0.571		R1 = OCH3; R2 = CF3; = −5.235; CT = 885.365; = 9.302; = 581.430; NHA = 6; NHD = 1	1.395
					R1 = OH; R2 = CF3; = −5.312; CT = 903.801; = 12.056; = 647.130; NHA = 6; NHD = 2	0.998
					R1 = OCH3; R2 = F; = −5.034; CT = 893.897; = 10.174; = 566.560; NHA = 4; NHD = 1	0.485
		R1 = OH; R2 = OH; N% = 12.380; = 1.080; = 3.131; NHA = 4; NHD = 3; MTI = 3497; TVC = 1.49 10^−05	0.170		R1 = R2 = OC2H5; = −4.696; CT = 927.241; = 11.222; = 622.010; NHA = 4; NHD = 1	0.464
					R1 = R2 = OCH3; = −4.731; CT = 916.967; = 11.469; = 599.470; NHA = 4; NHD = 1	0.442
					R1 = OCH3; R2 = OC(CH3)3; = −4.872; CT = 928.656; = 11.099; = 635.700; NHA = 4; NHD = 1	0.109
					R1 = OCH3; R2 = CH2NH2; = −4.801; CT = 934.561; = 14.185; = 660.500; NHA = 4; NHD = 2	0.122
		R1 = OH; R2 = meta-NH2; N% = 11.250; = 5.944; = 3.392; NHA = 5; NHD = 3; MTI = 17128; TVC = 2.23 10^−08	0.838		R1 = OCH3; R2 = para, meta -F: = −5.081; CT = 1006.097; = 13.267; = 762.370; NHA = 6; NHD = 1	0.308
		R1 = OCH3; R2 = para-NH2; N% = 10.850; = 7.114; = 3.295; NHA = 5; NHD = 2; MTI = 19138; TVC = 2.04 10^−08	0.607		R1 = OCH3; R2 = para NH2: = −4.966; CT = 1066.417; = 16.853; = 831.93; NHA = 5; NHD = 2	0.199
		R1 = OCH3; R2 = meta-NH2; N% = 10.850; = 6.193; = 3.353; NHA = 5; NHD = 2; MTI = 18992; TVC = 2.04 10^−08	0.309		R1 = OCH3; R2 = meta NH2: = −4.993; CT = 1066.417; = 16.853; = 831.930; NHA = 5; NHD = 2	0.166
		R1 = OH; R2 = H; N% = 7.820; = 5.631; = 3.483; NHA = 4; NHD = 2; MTI = 15585; TVC = 4.47 10^−08	0.381