Organic Compounds Based on (E)-N-Aryl-2-ethene-sulfonamide as Microtubule Targeted Agents in Prostate Cancer: QSAR Study

Table 1

Study compounds and radicals.

Compound	R	R1	pIC50
1	H	H	5.00
2	4-Cl	H	4.70
3	4-F	4-Br	5.00
4	4-F	4-OCH3	5.00
5	4-OCH3	4-OCH3	5.30
6	4-OCH3	2,4-(OCH3)2	4.82
7	4-OCH3	2,6-(OCH3)2	6.43
8	4-OCH3	2,4,6-(OCH3)3	6.7
9	4-OCH3	3,4,5-(OCH3)3	4.46
10	2,4,6-(OCH3)3	4-OCH3	5.12
11	4-OCH3	2,6-(OCH3)2, 4-OH	5.00
12	4-OCH3	2,4,6-F3	4.12
13	3-F, 4-OCH3	2,4,6-(OCH3)3	7.52
16	3-NH2, 4-OCH3	2,4,6-(OCH3)3	4.12
17	3-NO2, 4-OCH3	3,4,5-(OCH3)3	4.46
18	3-NH2, 4-OCH3	3,4,5-(OCH3)3	4.00
22	3-NO2, 4-F	2,4,6-(OCH3)3	5.00
23	3-NH2, 4-F	2,4,6-(OCH3)3	5.00
24	3,5-(NO2)2, 4-OCH3	2,4,6-(OCH3)3	5.00
25	3,5-(NH2)2, 4-OCH3	2,4,6-(OCH3)3	5.60
26	3-F, 4-OCH3	4-OCH3	5.30
27	3-F, 4-OCH3	2,3,4,5,6-F5	5.00
28	3-NO2, 4-OCH3	2,3,4,5,6-F5	4.00
29	3-NH2, 4-OCH3	2,3,4,5,6-F5	4.12
30	2,3,4,5,6-F5	3-NO2, 4-OCH3	4.00
31	2,3,4,5,6-F5	3-NH2, 4-OCH3	4.46
32	2,3,4,5,6-F5	2,3,4,5,6-F5	4.46
Compound	R2		pIC50
33	CH2		6.46
34	CH(CH3)		7.00
35	C(CH3)2		6.70
36	CH(C6H5)		5.60
37	CH(C6H44-F)		5.60
38	CH(C6H44-Br)		5.12
Compound	R2		pÏC50
39	CH2		6.40
40	CH(CH3)		7.40
41	C(CH3)2		7.15
42	CH(C6H5)		7.12
43	CH(C6H44-F)		7.12
44	CH(C6H44-Cl)		7.12
45	CH(C6H44-Br)		6.60