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Advances in Public Health
Volume 2016, Article ID 8504629, 9 pages
http://dx.doi.org/10.1155/2016/8504629
Research Article

Treatment Outcomes of Tuberculosis and Associated Factors in an Ethiopian University Hospital

1School of Pharmacy, Department of Clinical Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia
2Department of Clinical Pharmacy, College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia
3Department of Epidemiology, College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia
4Department of Health Informatics, Teda College of Health Sciences, Gondar, Ethiopia
5Department of Nursing, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia

Received 15 January 2016; Revised 24 March 2016; Accepted 6 April 2016

Academic Editor: Ronald J. Prineas

Copyright © 2016 Minaleshewa Biruk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Tuberculosis remains a major global health problem. It causes ill-health among millions of people each year and ranks alongside the human immunodeficiency virus (HIV) as a leading cause of death worldwide. Purpose. To assess the outcome of tuberculosis treatment and to identify factors associated with tuberculosis treatment outcome. Methods. A five-year retrospective cross-sectional study was employed and data were collected through medical record review. Data were analyzed using SPSS version 16 and binary and multiple logistic regression methods were used. A value of less than 0.05 was considered as statistically significant in the final model. Results. Out of the 1584 pulmonary TB patients (882 males and 702 females) including all age group, 60.1% had successful outcome and 39.9% had unsuccessful outcome. In the final multivariate logistic model, the odds of unsuccessful treatment outcome was higher among patients of weight category 30–39.9 kg (AOR = 1.51, 95% CI: 1.102–2.065) and smear negative pulmonary TB (AOR = 3.204, 95% CI: 2.277–4.509) and extrapulmonary TB (AOR = 3.175, 95% CI: 2.201–4.581) and retreatment (AOR = 6.733, 95% CI: 3.235–14.013) and HIV positive TB patients (AOR = 1.988, 95% CI: 1.393–2.838) and unknown HIV status TB patients (AOR = 1.506, 95% CI: 1.166–1.945) as compared to their respective comparison groups. Conclusion. In this study, high proportion of unsuccessful treatment outcome was documented. Therefore emphasis has to be given for patients with high risk of unsuccessful TB treatment outcome and targeted interventions should be carried out.