Comparison of General Practice and Pharmaceutical Dispensing Data for Pharmacoepidemiological Research: Assessing the Risk of Urinary-Tract Infections with Sodium Glucose Cotransporter 2 Inhibitors for Diabetes

Table 1

Cohorts’ demographics.

	MedicineInsight data			10 PBS data
	SGLT2	DPP-4	p-value	SGLT2	DPP-4	p-value
	(N=1977)	(N=1964)		(N=3120)	(N=12359)
	59.8	60.6		60.2	62.9
Mean age	(SD=11.4)	(SD=12.5)	0.027^a	(SD=11.0)	(SD=13.4)	<0.0001^a
Gender
Females	887 (45)	800 (41)	0.009^b	1333 (43)	5333 (43)	0.667^b
Males	1090 (55)	1164 (59)		1787 (57)	7026 (57)
Comorbidity (prior 12 months)
No comorbidity	148 (8)	300 (15)		279 (9)	719 (6)
One or two	564 (28)	659 (34)	<0.0001^b	1016 (33)	4285 (35)	<0.0001^b
Three or more	1265 (64)	1005 (51)		1825 (58)	7355 (59)
Prior UTIs (prior 6 months)	67 (3.4)	82 (4.2)	0.196 ^b	78 (2.5)	441 (3.5)	0.003 ^b

Student’s t-test; Chi-square test.
Note: Prior UTIs were identified only by medicines specific for UTIs (trimethoprim, nitrofurantoin, norfloxacin) in the 10 PBS data, while in the MedicineInsight data we accounted for UTI medicines (74 of all cases) and diagnosis/reasons for encounters (26 of all cases).