Linear Mixed Modeling of CD4 Cell Counts of HIV-Infected Children Treated with Antiretroviral Therapy
Table 3
Parameter estimate of the linear mixed-effect model with random intercept and randomslope.
Predictor variables
t value
value
95% CI
Intercept
30.12
1.05
28.85
0.001
(28.05, 32.19)
Observation time
0.17
0.04
4.25
0.001
(0.08, 0.25)
Age
0.78
0.11
7.09
0.001
(−1.01, −0.54)
WHO stage; stage I (Ref)
—
—
−5.15
0.010
—
Stage II
−1.17
0.89
−1.31
0.190
(−2.93, 0.58)
Stage III
−6.43
1.19
−5.40
0.001
(−8.78, −4.08)
Stage IV
−9.28
1.54
−6.03
0.001
(−12.34, −6.23)
TB; negative (Ref)
—
—
1.38
0.034
—
Positive
−2.88
0.66
−4.36
0.001
(−4.20, −1.57)
Functional status; ambulatory (Ref)
—
—
1.78
0.045
—
Bedridden
−0.67
0.92
−0.72
0.163
(−2.50, 1.14)
Working
1.13
0.70
1.61
0.010
(−0.26, 2.52)
TimeWHO; timestage I (Ref)
—
—
4.50
0.028
—
Time∗stage II
0.05
0.04
1.25
0.184
(−0.02, 0.14)
Timestage III
0.16
0.06
2.66
0.014
(0.03, 0.29)
Timestage IV
−0.23
0.15
−1.53
0.113
(−0.53, 0.05)
Timeage
0.02
0.01
2.00
0.012
(0.003, 0.02)
Note: represent the estimated parameters; is the standard error of estimated parameters; represent the significant p value at 5% level of significance; and Ref denotes the reference category.
