Table of Contents Author Guidelines Submit a Manuscript
Advances in Preventive Medicine
Volume 2011 (2011), Article ID 127369, 7 pages
Research Article

Birth Outcomes of Newborns after Folic Acid Supplementation in Pregnant Women with Early and Late Pre-Eclampsia: A Population-Based Study

1Second Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary
2Department of Pulmonology, Elisabeth Teaching Hospital, Sopron, Hungary
3Foundation for the Community Control of Hereditary Diseases, Törökvész lejtö 32, 1028 Budapest, Hungary

Received 20 May 2010; Revised 25 September 2010; Accepted 1 November 2010

Academic Editor: Jim Tartaglia

Copyright © 2011 Ferenc Bánhidy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the rate of preterm birth and low birth weight in the newborns of pregnant women with early and late onset pre-eclampsia according to folic acid supplementation. Study design. Birth outcomes of newborns were evaluated in 1,017 (2.7%) pregnant women with medically recorded pre-eclampsia and 37,134 pregnant women without pre-eclampsia as reference in the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980–1996, in addition these study groups were differentiated according to the supplementation of high dose of folic acid alone from early pregnancy. Results. Pregnant women with pre-eclampsia associated with a higher rate of preterm birth (10.2% versus 9.1%) and low birthweight (7.9% versus 5.6%). There was a lower risk of preterm birth (6.8%) of newborn infants born to pregnant women with early onset pre-eclampsia after folic acid supplementation from early pregnancy though the rate of low birthweight was not reduced significantly. There was no significant reduction in the rate of preterm birth and low birthweight in pregnant women with late onset pre-eclampsia after folic acid supplementation. Conclusion. The rate of preterm birth in pregnant women with early onset pre-eclampsia was reduced moderately by high doses of folic acid supplementation from early pregnancy.