Advances in Pharmacological and Pharmaceutical Sciences / 2010 / Article / Tab 1

Research Article

Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition

Table 1

IC50 values ( M) of testosterone relaxant effect on rat aortic rings contracted with BAY and with KCl (60 mM) alone or in the presence of the following drugs: the channel blocker 4-aminopyridine (4-AP; 2 mM), the channel blocker tetraethylammonium (TEA; 1 mM), the channel blocker glibenclamide (GLI; 10  M) and the testosterone receptor antagonists flutamide (10  M). Each value represents the mean ± SEM from the number of experiments shown in brackets. * versus testosterone IC50 obtained in KCl-contracted arteries, Student's t-test.

AgentsTestosterone IC50 ( M)

BAY12.94 ± 1.92 (n = 6)*
KCl29.88 ± 1.12 (n = 5)
KCl + TEA23.60 ± 1.06 (n = 4)
KCl + 4-AP31.24 ± 1.15 (n = 5)
KCl + GLI27.87 ± 1.21 (n = 3)
KCl + Flutamide20.67 ± 1.26 (n = 4)

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