The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion
Figure 4
Time course of cardiac function parameters (LVDP) from sham, I/R, I/R+PMN, I/R+PMN+BH4 (10 M), and I/R+PMN+BH2 (100 M) groups. There was no significant difference in baseline values among these groups. The sham group maintained the same LVDP throughout the 80 minutes protocol. The I/R+PMN and I/R+PMN groups exhibited a significant and sustained reduction in LVDP during the 45 minutes of reperfusion compared to sham. I/R and I/R+PMN+BH4 groups exhibited significant restoration of LVDP during the 45 minutes reperfusion compared to I/R+PMN group. All values are expressed as mean ± SEM. ( from I/R+PMN values).
