Advances in Pharmacological and Pharmaceutical Sciences / 2010 / Article / Fig 5

Research Article

The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion

Figure 5

Initial and final LVDP expressed in mmHg from different experimental groups. Hearts were perfused in the presence or absence of PMNs. PMNs induced a significant decrease in LVDP, which was attenuated by the BH4 (10  M), not by BH2 (100  M). L-NAME (50  M) blocked the cardioprotective effect of BH4 treatment. All values are expressed as mean SEM. Numbers of hearts are at the bottom of the bars. All drugs are in M concentrations. ( from final I/R+PMN values; NS, not significant compared to initial LVDP values).

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