The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion
Figure 8
Histological assessment of total intravascular/infiltrated PMNs and vascular adhered PMNs in isolated postreperfused rat heart tissue from different experimental groups. The total intravascular/infiltrated PMNs in sham, I/R and I/R+PMN+BH4 (10 M) groups were significantly reduced compared to that in I/R+PMN group. Similarly, the vascular adhered PMNs in sham, I/R, I/R+PMN+BH4 (5 M), and I/R+PMN+BH4 (10 M) groups were also significantly reduced compared to that in I/R+PMN group. All values are expressed as mean SEM. Numbers of samples are listed in the box with the bars. All drugs are in M concentrations. ( from total intravascular/infiltrated PMNs in I/R+PMN group; from vascular adhered PMNs in I/R+PMN group).
