The Mushroom <i>Agaricus blazei</i> Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

<table>The Ying and Yang of adaptive immunity. There is a balance between the Th responses in such a way that Th1 inhibits Th2, which inhibits Th17 and which again inhibits the Treg response. “Over-shoot” of Th1 and Th17 responses in susceptible individuals can result in autoimmune disorders. The regulation by T reg cells results in immunosuppression and tolerance. The <i>Agaricus</i> mushroom shifts the Th1/Th2 balance towards increased Th1 response, which in addition to intracellular pathogens also fights cancer.</table>

Advances in Pharmacological and Pharmaceutical Sciences

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Figure 6

Figure 6: The Mushroom <i>Agaricus blazei</i> Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation 

Figure 6 | The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation 