The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

Table 1

Reported in vivo antitumor effect of the mushroom Agaricus blazei Murill.

Tumor/related activity	In vivo effects of Agaricus bM	Refs. (no., year, country)
Fibrosarcoma	Inhibition of tumor size and neoangiogenesis	[4] 1994, [40] 1998, [3] 2001, [39] 2004, Japan
Gynecological cancer*	Increased NK-cell activity and increased quality of life (QOL)	[31] 2004, Republic of Korea
Ovarian cancer	Inhibition of metastasis	[41], 2005 Japan
Lung cancer	Inhibition of metastasis	[39] 2004, [41] 2005, Japan
Leukemia*	Inhibition	[42] 1994, Japan
Myeloma	Inhibition of tumor size	[43] 2007, Japan
Prostate cancer	Reduced tumor growth and neoangiogenesis; No significant effect on PSA values*	[44] 2009, Taiwan; [45] 2010, Japan
Carcinogenicity	No	[25] 2008, Republic of Korea

*Human studies, otherwise studies in mice.