Table of Contents Author Guidelines Submit a Manuscript
Advances in Pharmacological Sciences
Volume 2011 (2011), Article ID 195271, 5 pages
http://dx.doi.org/10.1155/2011/195271
Research Article

Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

1Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur 440018, India
2Department of Pharmacology, Shree Sathya Sai Medical College and Research Institute, Chennai 603108, India

Received 21 August 2011; Revised 3 November 2011; Accepted 3 November 2011

Academic Editor: Mustafa F. Lokhandwala

Copyright © 2011 Ganesh N. Dakhale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [22 citations]

The following is the list of published articles that have cited the current article.

  • Yong-Long Wang, Zuo-Qi Xiao, Shan Liu, Luo-Sheng Wan, Yao-Dong Yue, Yu-Tang Zhang, Zhao-Xia Liu, and Jia-Chun Chen, “Antidiabetic effects of Swertia macrosperma extracts in diabetic rats,” Journal of Ethnopharmacology, 2013. View at Publisher · View at Google Scholar
  • Wei Wang, Chao Liu, Jie Yang, Xueting Cai, Wuguang Lu, Zhenhua Gu, and Peng Cao, “Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis,” Journal of Traditional Chinese Medicine, vol. 33, no. 1, pp. 98–102, 2013. View at Publisher · View at Google Scholar
  • Dilsad Ozerkan, Nesrin Ozsoy, and Suna Cebesoy, “Response of thymus lymphocytes to streptozotocin-induced diabetes and exogenous vitamin C administration in rats,” Microscopy, vol. 63, no. 6, pp. 409–417, 2014. View at Publisher · View at Google Scholar
  • Omotayo O. Erejuwa, “Effect of honey in diabetes mellitus: Matters arising,” Journal of Diabetes and Metabolic Disorders, vol. 13, no. 1, 2014. View at Publisher · View at Google Scholar
  • Karina Huynh, Bianca C. Bernardo, Julie R. McMullen, and Rebecca H. Ritchie, “Diabetic Cardiomyopathy: Mechanisms and New Treatment Strategies Targeting Antioxidant Signaling Pathways,” Pharmacology & Therapeutics, 2014. View at Publisher · View at Google Scholar
  • Yan-Jun Xu, Paramjit S. Tappia, Nirankar S. Neki, and Naranjan S. Dhalla, “Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants,” Heart Failure Reviews, vol. 19, no. 1, pp. 113–121, 2014. View at Publisher · View at Google Scholar
  • Diego Fernando Garcia-Diaz, Patricia Lopez-Legarrea, Pablo Quintero, and Jose Alfredo Martinez, “Vitamin C in the treatment and/or prevention of obesity,” Journal of Nutritional Science and Vitaminology, vol. 60, no. 6, pp. 367–379, 2014. View at Publisher · View at Google Scholar
  • Arrigo F.G. Cicero, and Alessandro Colletti, “Role of phytochemicals in the management of metabolic syndrome,” Phytomedicine, 2015. View at Publisher · View at Google Scholar
  • Mohammed S. Ellulu, Asmah Rahmat, Ismail Patimah, Huzwah Khaza'ai, and Yehia Abed, “Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial,” Drug Design Development And Therapy, vol. 9, pp. 3405–3412, 2015. View at Publisher · View at Google Scholar
  • Joseph Shay, Hosam A. Elbaz, Icksoo Lee, Steven P. Zielske, Moh H. Malek, and Maik Hüttemann, “Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration,” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1–13, 2015. View at Publisher · View at Google Scholar
  • Narinder P.S. Dhillon, Chung-Cheng Lin, Zhanyong Sun, Peter M. Hanson, Dolores R. Ledesma, Sandra D. Habicht, and Ray-Yu Yang, “Varietal and harvesting stage variation in the content of carotenoids, ascorbic acid and tocopherols in the fruit of bitter gourd (Momordica charantia L.),” Plant Genetic Resources: Characterisation and Utilisation, vol. 15, no. 3, pp. 248–259, 2016. View at Publisher · View at Google Scholar
  • Ammar W. Ashor, Mario Siervo, Femke van der Velde, Naomi D. Willis, and John C. Mathers, “Systematic review and meta-analysis of randomised controlled trials testing the effects of vitamin C supplementation on blood lipids,” Clinical Nutrition, vol. 35, no. 3, pp. 626–637, 2016. View at Publisher · View at Google Scholar
  • Ademola Ayeleso, Oluwafemi Oguntibeju, Nicole Brooks, and Emmanuel Mukwevho, “Natural antioxidant vitamins: A review of their beneficial roles in management of diabetes mellitus and its complications,” Tropical Journal of Pharmaceutical Research, vol. 15, no. 6, pp. 1341–1348, 2016. View at Publisher · View at Google Scholar
  • Tagang Aluwong, Joseph Ayo, Alkali Kpukple, and Olusola Oladipo, “Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C,” Nutrients, vol. 8, no. 5, pp. 151, 2016. View at Publisher · View at Google Scholar
  • Shaun A. Mason, Paul A. Della Gatta, Rod J. Snow, Aaron P. Russell, and Glenn D. Wadley, “Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study,” Free Radical Biology and Medicine, 2016. View at Publisher · View at Google Scholar
  • John Pearson, Juliet Pullar, Renee Wilson, Janet Spittlehouse, Margreet Vissers, Paula Skidmore, Jinny Willis, Vicky Cameron, and Anitra Carr, “Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study,” Nutrients, vol. 9, no. 8, pp. 831, 2017. View at Publisher · View at Google Scholar
  • Syed Wasif Gillani, Syed Azhar Syed Sulaiman, Mohi Iqbal Mohammad Abdul, and Mirza R. Baig, “Combined effect of metformin with ascorbic acid versus acetyl salicylic acid on diabetes-related cardiovascular complication; a 12-month single blind multicenter randomized control trial,” Cardiovascular Diabetology, vol. 16, no. 1, 2017. View at Publisher · View at Google Scholar
  • Fotini Karavassili, Alexandros Valmas, Stavroula Fili, Christos Georgiou, and Irene Margiolaki, “In Quest for Improved Drugs against Diabetes: The Added Value of X-ray Powder Diffraction Methods,” Biomolecules, vol. 7, no. 3, pp. 63, 2017. View at Publisher · View at Google Scholar
  • Mabel Kar-Wai Yan, and Hanan Khalil, “Vitamin supplements in type 2 diabetes mellitus management: A review,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017. View at Publisher · View at Google Scholar
  • Noori Al-Waili, Hamza Al-Waili, Thia Al-Waili, and Khelod Salom, “Natural antioxidants in the treatment and prevention of diabetic nephropathy; a potential approach that warrants clinical trials,” Redox Report, pp. 1–20, 2017. View at Publisher · View at Google Scholar
  • Mohammed S. Ellulu, “Obesity, cardiovascular disease, and role of vitamin C on inflammation: a review of facts and underlying mechanisms,” Inflammopharmacology, 2017. View at Publisher · View at Google Scholar
  • Tirani Bahari, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Keisuke Miki, Masashi Ishizu, and Kokichi Arisawa, “Nutrient-Derived Dietary Patterns and Their Association With Metabolic Syndrome in a Japanese Population,” Journal of Epidemiology, 2017. View at Publisher · View at Google Scholar