Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

Table 4

Comparison of effects of metformin with vitamin C and in combination with placebo on FBG, PPBG, HbA1c, and plasma AA at 12 weeks in patients with type 2 diabetes mellitus taking into account the change from baseline.

Parameter	Change from baseline at 12 weeks		𝑃 (unpaired)
	Group A	Group B
FBG	−16.45±3.80	−5.42±2.65	<0.05
PPBG	−15.54±2.42	−6.93±2.99	<0.05
HbA1c	−0.451±0.07	−0.169±0.10	<0.05
Plasma AA	0.19±0.01	0.02±0.01	<0.001

𝑛=33 in each group, Group A: vitamin C-treated group, Group B: placebo-treated group, FBG: fasting blood glucose, PPBG: postmeal blood glucose, HbA1c: glycosylated hemoglobin, plasma AA: plasma ascorbic acid. FBG, PPBG, and plasma AA are measured in mg/dL.