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Advances in Pharmacological Sciences
Volume 2011, Article ID 740687, 6 pages
http://dx.doi.org/10.1155/2011/740687
Research Article

Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

Pharmacology Department, Centre of Natural Products, National Centre for Scientific Research, Avenue 25 and 158 Street Cubanacán, Havana City 6880, Cuba

Received 9 August 2011; Revised 23 September 2011; Accepted 23 September 2011

Academic Editor: Mustafa F. Lokhandwala

Copyright © 2011 Vivian Molina Cuevas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Ramakrishnan and R. C. Salinas, “Peptic ulcer disease,” American Family Physician, vol. 76, no. 7, pp. 1005–1012, 2007. View at Google Scholar · View at Scopus
  2. C. Tasman-Jones, “Pathogenesis of peptic ulcer disease and gastritis: importance of aggressive and cytoprotective factors,” Scandinavian Journal of Gastroenterology, vol. 21, supplement 22, pp. 1–5, 1986. View at Google Scholar · View at Scopus
  3. L. Laine, K. Takeuchi, and A. Tarnawski, “Gastric mucosal defense and cytoprotection: bench to bedside,” Gastroenterology, vol. 135, no. 1, pp. 41–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Kountouras, D. Chatzopoulos, and C. Zavos, “Reactive oxygen metabolites and upper gastrointestinal diseases,” Hepato-Gastroenterology, vol. 48, no. 39, pp. 743–751, 2001. View at Google Scholar · View at Scopus
  5. S. Demir, M. Yilmaz, M. Köseoğlu, N. Akalin, D. Aslan, and A. Aydin, “Role of free radicals in peptic ulcer and gastritis,” Turkish Journal of Gastroenterology, vol. 14, no. 1, pp. 39–43, 2003. View at Google Scholar · View at Scopus
  6. B. J. Whittle, “Gastrointestinal effects of nonsteroidal anti-inflammatory drugs,” Fundamental and Clinical Pharmacology, vol. 17, no. 3, pp. 301–313, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Lamarque, “Pathogenesis of gastroduodenal lesions induced by non-steroidal anti-inflammatory drugs,” Gastroenterologie Clinique et Biologique, vol. 28, pp. C18–C26, 2004. View at Google Scholar · View at Scopus
  8. G. Sener-Muratoğlu, K. Paskaloğlu, S. Arbak et al., “Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats,” Digestive Diseases and Sciences, vol. 46, no. 2, pp. 318–330, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Pohle, T. Brzozowski, J. C. Becker et al., “Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin C,” Alimentary Pharmacology and Therapeutics, vol. 15, no. 5, pp. 677–687, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Jainu and S. Devi, “Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis,” Journal of Herbal Pharmacotherapy, vol. 5, no. 3, pp. 33–42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Jainu, V. Mohan, and S. Devi, “Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats,” Journal of Ethnopharmacology, vol. 104, no. 3, pp. 302–305, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Hernandez-Munoz, C. Montiel-Ruiz, and O. Vazquez-Martinez, “Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats,” Laboratory Investigation, vol. 80, supplement 8, pp. 1161–1169, 2000. View at Google Scholar · View at Scopus
  13. H. Araki, H. Ukawa, Y. Sugawa, K. Yagi, K. Suzuki, and K. Takeuchi, “The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach,” Alimentary Pharmacology & Therapeutics, vol. 14, supplement 1, pp. 116–124, 2000. View at Google Scholar · View at Scopus
  14. A. Slomiany, M. Morita, S. Sano, J. Piotrowski, D. Skrodzka, and B. L. Slomiany, “Effect of ethanol on gastric mucus glycoprotein synthesis, translocation, transport, glycosylation, and secretion,” Alcoholism: Clinical and Experimental Research, vol. 21, no. 3, pp. 417–423, 1997. View at Google Scholar · View at Scopus
  15. S. Sánchez-Fidalgo, I. Martín-Lacave, M. Illanes, and V. Motilva, “Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor,” European Journal of Pharmacology, vol. 505, no. 1–3, pp. 187–194, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Amanvermez, O. K. Tunçel, S. Demir, M. Kefeli, Y. Bek, and C. Celik, “Protective effects of cysteine, methionine and vitamin C on the stomach in chronically alcohol treated rats,” Journal of Applied Toxicology, vol. 28, no. 5, pp. 591–598, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. R. E. Beyer, “The role of ascorbate in antioxidant protection of biomembranes: interaction with vitamin E and coenzyme Q,” Journal of Bioenergetics and Biomembranes, vol. 26, no. 4, pp. 349–358, 1994. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Jonas, A. Dwenger, and A. Hager, “In vitro effect of ascorbic acid on neutrophil-endothelial cell interaction,” Journal of Bioluminescence and Chemiluminescence, vol. 8, no. 1, pp. 15–20, 1993. View at Google Scholar · View at Scopus
  19. J. C. Becker, N. Grosser, P. Boknik, H. Schröder, W. Domschke, and T. Pohle, “Gastroprotection by vitamin C—a heme oxygenase-1-dependent mechanism?” Biochemical and Biophysical Research Communications, vol. 312, no. 2, pp. 507–512, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. P. C. Konturek, J. Kania, E. G. Hahn, and J. W. Konturek, “Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase,” Journal of Physiology and Pharmacology, vol. 57, supplement 5, pp. 125–136, 2006. View at Google Scholar · View at Scopus
  21. D. C. Liebler, “Antioxidant chemistry of alpha-tocopherol in biological systems. Roles of redox cycles and metabolism,” Subcellular Biochemistry, vol. 30, pp. 301–317, 1998. View at Google Scholar · View at Scopus
  22. N. Yoshida, T. Yoshikawa, H. Manabe et al., “Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells,” Journal of Leukocyte Biology, vol. 65, no. 6, pp. 757–763, 1999. View at Google Scholar · View at Scopus
  23. D. Rocksén, B. Ekstrand-Hammarström, L. Johansson, and A. Bucht, “Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation,” American Journal of Respiratory Cell and Molecular Biology, vol. 28, no. 2, pp. 199–207, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Jaarin, M. Renuvathani, M. I. Nafeeza, and M. T. Gapor, “Effect of palm vitamin E on the healing of ethanol-induced gastric injury in rats,” International Journal of Food Sciences and Nutrition, vol. 51, pp. S31–S41, 2000. View at Google Scholar · View at Scopus
  25. K. Jaarin, M. T. Gapor, M. I. Nafeeza, and A. M. Fauzee, “Effect of various doses of palm vitamin E and tocopherol on aspirin-induced gastric lesions in rats,” International Journal of Experimental Pathology, vol. 83, no. 6, pp. 295–302, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Fesharaki, A. Nasimi, S. Mokhtari, R. Mokhtari, R. Moradian, and N. Amirpoor, “Reactive oxygen metabolites and anti-oxidative defenses in aspirin-induced gastric damage in rats: gastroprotection by Vitamin E,” Pathophysiology, vol. 13, no. 4, pp. 237–243, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Balu, P. Sangeetha, G. Murali, and C. Panneerselvam, “Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract,” International Journal of Developmental Neuroscience, vol. 23, no. 6, pp. 501–507, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Balu, P. Sangeetha, D. Haripriya, and C. Panneerselvam, “Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extract,” Neuroscience Letters, vol. 383, no. 3, pp. 295–300, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Devi, A. B. Jolitha, and N. Ishii, “Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats,” Medical Science Monitor, vol. 12, no. 4, pp. 124–129, 2006. View at Google Scholar · View at Scopus
  30. J. Busserolles, E. Gueux, B. Balasińska et al., “In vivo antioxidant activity of procyanidin-rich extracts from grape seed and pine (Pinus maritima) bark in rats,” International Journal for Vitamin and Nutrition Research, vol. 76, no. 1, pp. 22–27, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. I. Rodríguez, J. Illnait, V. Molina et al., “Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects,” Latin American Journal of Pharmacy, vol. 29, pp. 255–562, 2010. View at Google Scholar
  32. P. Kar, D. Laight, H. K. Rooprai, K. M. Shaw, and M. Cummings, “Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity,” Diabetic Medicine, vol. 26, no. 5, pp. 526–531, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Saito, H. Hosoyama, T. Ariga, S. Kataoka, and N. Yamaji, “Antiulcer activity of grape seed extract and procyanidins,” Journal of Agricultural and Food Chemistry, vol. 46, no. 4, pp. 1460–1464, 1998. View at Google Scholar · View at Scopus
  34. H. Zengil, E. Onuk, Z. S. Ercan, and R. K. Turker, “Protective effect of iloprost and UK 38 485 against gastric mucosal damage induced by various stimuli,” Prostaglandins Leukotrienes and Medicine, vol. 30, no. 2-3, pp. 61–67, 1987. View at Google Scholar · View at Scopus
  35. A. Ohara, S. Sugiyama, H. Hoshino et al., “Reduction of adverse effects of indometacin by anti-allergic drugs in rat stomachs,” Arzneimittel-Forschung/Drug Research, vol. 42, no. 9, pp. 1115–1118, 1992. View at Google Scholar · View at Scopus
  36. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Google Scholar · View at Scopus
  37. P. A. Kumar and G. Rajagopal, “Lipid peroxidation in erythrocytes of patients with type 2 diabetes mellitus,” Indian Journal of Clinical Biochemistry, vol. 18, no. 1, pp. 71–74, 2003. View at Google Scholar · View at Scopus
  38. R. Premanand, P. H. S. Kumar, and A. Mohan, “Study of thiobarbituric reactive substances and total reduced glutathione as indices of oxidative stress in chronic smokers with and without chronic obstructive pulmonary disease,” The Indian Journal of Chest Diseases and Allied Sciences, vol. 49, no. 1, pp. 9–12, 2007. View at Google Scholar · View at Scopus
  39. S. V. Tembhurne and D. M. Sakarkar, “Protective effect of Murraya koenigii (L) leaves extract in spreptozotocin induced diabetics rats involving possible antioxidant mechanism,” Journal of Medicinal Plants Research, vol. 4, pp. 2418–2423, 2010. View at Google Scholar
  40. T. Matsunami, Y. Sato, T. Sato, and M. Yukawa, “Antioxidant status and lipid peroxidation in diabetic rats under hyperbaric oxygen exposure,” Physiological Research, vol. 59, no. 1, pp. 97–104, 2010. View at Google Scholar · View at Scopus
  41. M. A. Marxwell, S. M. Haas, L. L. Beiber, and N. E. Tolbert, “A modification of the Lowry procedure to simplify protein determination in membrane lipoprotein samples,” Analytical Biochemistry, vol. 87, pp. 206–209, 1987. View at Google Scholar
  42. M. G. Repetto and S. F. Llesuy, “Antioxidant properties of natural compounds used in popular medicine for gastric ulcers,” Brazilian Journal of Medical and Biological Research, vol. 35, no. 5, pp. 523–534, 2002. View at Google Scholar · View at Scopus
  43. T. Brzozowski, S. KwiecieÅ, P. Konturek et al., “Comparison of nitric oxide-releasing NSAID and vitamin C with classic NSAID in healing of chronic gastric ulcers; involvement of reactive oxygen species,” Medical Science Monitor, vol. 7, no. 4, pp. 592–599, 2001. View at Google Scholar · View at Scopus
  44. J. C. Becker, N. Grosser, P. Boknik, H. Schröder, W. Domschke, and T. Pohle, “Gastroprotection by vitamin C—a heme oxygenase-1-dependent mechanism?” Biochemical and Biophysical Research Communications, vol. 312, no. 2, pp. 507–512, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Ohta, Y. Imai, S. Kaida, Y. Kamiya, M. Kawanishi, and I. Hirata, “Vitamin E protects against stress-induced gastric mucosal lesions in rats more effectively than vitamin C,” BioFactors, vol. 36, no. 1, pp. 60–69, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Z. Wang, G. P. Huang, G. L. Yin et al., “Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats,” Cellular Physiology and Biochemistry, vol. 20, no. 1–4, pp. 205–212, 2007. View at Publisher · View at Google Scholar · View at Scopus