Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death in Permanent versus Reperfusion Injury

Figure 4

Cardiovascular responses to DPN (1 mg/kg) or 7.5% DMSO pretreatment (i.v.; 30 minutes) prior to I/R. (a) Representative physiograph tracings of changes in arterial pressure and heart rate to phenylephrine injection (PE; 2.5 μg/mL). Graphs represent average changes in mean arterial pressure (MAP; (b)), heart rate (HR; (c)), and baroreceptor reflex sensitivity (BRS; (d)). The first dashed lines represents the times at which the MCA was occluded and the second line indicates when blood flow was returned (reperfusion). Each data point represents the mean ± S.E.M (𝑛 = 4–6/group), and *indicates significance (𝑃≤.05) from baseline values.

(a)

(b)

(c)

(d)