Table of Contents Author Guidelines Submit a Manuscript
Advances in Pharmacological Sciences
Volume 2012, Article ID 134523, 10 pages
http://dx.doi.org/10.1155/2012/134523
Review Article

An Overview of the CNS-Pharmacodynamic Profiles of Nonselective and Selective GABA Agonists

1Phase I Unit of Clinical Pharmacological Research Center, Peking Union Medical College Hospital, 100032 Beijing, China
2Centre for Human Drug Research, 2333 CL Leiden, The Netherlands

Received 9 July 2011; Revised 2 December 2011; Accepted 7 December 2011

Academic Editor: Keith Wafford

Copyright © 2012 Xia Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Xia Chen, Gabriel Jacobs, Marieke de Kam, Judith Jaeger, Jaakko Lappalainen, Paul Maruff, Mark A. Smith, Alan J. Cross, Adam Cohen, and Joop van Gerven, “The central nervous system effects of the partial GABA-A alpha(2,3)-selective receptor modulator AZD7325 in comparison with lorazepam in healthy males,” British Journal of Clinical Pharmacology, vol. 78, no. 6, pp. 1298–1314, 2014. View at PublisherView at Google Scholar
  • Erik T. te Beek, Xia Chen, Gabriël E. Jacobs, Kimberly J. Nahon, Marieke L. de Kam, Jaakko Lappalainen, Alan J. Cross, Joop M. A. van Gerven, and Justin L. Hay, “The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels,” Clinical Pharmacology in Drug Development, vol. 4, no. 2, pp. 149–154, 2015. View at PublisherView at Google Scholar
  • Xia Chen, Gabriel Jacobs, Marieke L. de Kam, Judith Jaeger, Jaakko Lappalainen, Paul Maruff, Mark A. Smith, Alan J. Cross, Adam Cohen, and Joop van Gerven, “AZD6280, a Novel Partial gamma-Aminobutyric Acid A Receptor Modulator, Demonstrates a Pharmacodynamically Selective Effect Profile in Healthy Male Vol,” Journal Of Clinical Psychopharmacology, vol. 35, no. 1, pp. 22–33, 2015. View at PublisherView at Google Scholar
  • Yu-Peng Ren, Ru-Jia Xie, Scott Marshall, Liang Li, Tian-Yan Zhou, and Wei Lu, “Model-based meta-analysis of the effects of non-selective and alpha(1)-selective GABA(A) receptor agonists in healthy volunteers,” European Journal Of Clinical Pharmacology, vol. 71, no. 10, pp. 1209–1221, 2015. View at PublisherView at Google Scholar
  • Antonia M. Do Rocio Binder Do Prado, Sérgio A. Ignácio, Edvaldo A. R. Rosa, Luciana R. A. Alanis, Youssef Sari, Antonio A. S. De Lima, Mariana Rinaldi, Patrícia V. C. Bettega, Ana M. T. Grégio, Aline C. B. R. Johann, Fábio Rocha, and Silvana Da Silva, “Histomorphometric analysis of salivary gland in wistar rats treated chronically with two benzodiazepines,” Current Pharmaceutical Biotechnology, vol. 16, no. 6, pp. 573–578, 2015. View at PublisherView at Google Scholar
  • A. F. Cohen, J. Burggraaf, J. M. A. van Gerven, M. Moerland, G. J. Groeneveld, A. F. Cohen, J. Burggraaf, J. M. A. van Gerven, M. Moerland, and G. J. Groeneveld, “The Use of Biomarkers in Human Pharmacology (Phase I) Studies,” Annual Review Of Pharmacology And Toxicology, Vol 55, vol. 55, pp. 55–+, 2015. View at PublisherView at Google Scholar
  • Justin Luke Hay, Johannes Marinus Van Gerven, and Geert Jan Groeneveld, “Measuring blood–brain barrier penetration using the NeuroCart, a CNS test battery,” Drug Discovery Today: Technologies, vol. 20, pp. 27–34, 2016. View at PublisherView at Google Scholar
  • Rob G. J. A. Zuiker, Xia Chen, Ole Osterberg, Naheed R. Mirza, Pierandrea Muglia, Marieke de Kam, Erica S. Klaassen, and Joop M. A. van Gerven, “NS11821, a partial subtype-selective GABA(A) agonist, elicits selective effects on the central nervous system in randomized controlled trial with heal,” Journal Of Psychopharmacology, vol. 30, no. 3, pp. 253–262, 2016. View at PublisherView at Google Scholar
  • Ricardo Alvarez-Jimenez, Sven C. van Dijkman, Meindert Danhof, and Oscar Della Pasqua, “Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection – a long way to go,” Expert Opinion on Drug Metabolism and Toxicology, vol. 12, no. 10, pp. 1143–1156, 2016. View at PublisherView at Google Scholar
  • Xia Chen, Freerk Broeyer, Marieke de Kam, Joke Baas, Adam Cohen, and Joop van Gerven, “Pharmacodynamic response profiles of anxiolytic and sedative drugs,” British Journal of Clinical Pharmacology, 2017. View at PublisherView at Google Scholar
  • Ulrich Ettinger, Mitul A Mehta, Philip J Corr, Steven CR Williams, Inga Meyhöfer, Veena Kumari, and Adam M Perkins, “Effects of lorazepam on saccadic eye movements: the role of sex, task characteristics and baseline traits,” Journal of Psychopharmacology, vol. 32, no. 6, pp. 678–690, 2018. View at PublisherView at Google Scholar
  • Stefan Duschek, Alexandra Hoffmann, Casandra I. Montoro, Angela Bair, Gustavo A. Reyes del Paso, and Ulrich Ettinger, “Cerebral blood flow modulations during antisaccade preparation in chronic hypotension,” Psychophysiology, pp. e13305, 2018. View at PublisherView at Google Scholar
  • Xia Chen, Joop van Gerven, Adam Cohen, and Gabriel Jacobs, “Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety,” Acta Pharmacologica Sinica, 2018. View at PublisherView at Google Scholar
  • Joop van Gerven, “Functional Measurements of Central Nervous System Drug Effects in Early Human Drug Development,” Translational Medicine in CNS Drug Development, vol. 29, pp. 39–61, 2019. View at PublisherView at Google Scholar
  • Coen RH Huizinga, Rob G Zuiker, Marieke L de Kam, Dimitrios Ziagkos, Jorrit Kuipers, Yuri Mejia, Adam F Cohen, and Joop MA van Gerven, “Evaluation of simulated driving in comparison to laboratory-based tests to assess the pharmacodynamics of alprazolam and alcohol,” Journal of Psychopharmacology, 2019. View at PublisherView at Google Scholar