Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers: Short Review

Figure 2

Stress-induced modulations in dopaminergic system and gastric ulcer. Hormonal pathways by which psychological and physical stress induce modulations in stomach functioning, resulting in an increase production of gastric ulceration and modulation of dopaminergic system. Up arrows indicate increased response, down arrows indicate decreased response, triangles indicate possible therapeutic targets. Abbreviations: CRH: corticotrophin-releasing hormone; ACTH: adrenocorticotrophin-releasing factor; PGE₂ and prostaglandin E₂; HCL: hydrochloric acid; H⁺K⁺-ATPase: hydrogen-potassium ATPase: DA: dopamine; DA-1R: DA receptor 1; DA-2R: DA receptor 2.