Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze

Table 2

Effect of palmatine and other drugs employed on escape latency (EL) of mice using Morris water maze.

Treatments	Dose (kg)^−1	EL (sec) Day-6	EL (sec) Day-7	EL (sec) Day-8	EL (sec) Day-9
Control (vehicle) for 10 days	10 mL	105.90 ± 3.28	96.34 ± 3.44	78.38 ± 3.70	54.19 ± 3.44
Physostigmine for 10 days	0.1 mg	104.31 ± 3.06	101.25 ± 2.51	74.09 ± 2.45	33.5 ±2.66^c
Scopolamine	0.4 mg	106.62 ± 18.16	87.66 ± 3.75	69.63 ± 3.49	44.44 ± 2.81^b
Diazepam	1 mg	105.96 ± 2.59	91.66 ± 2.48	69.47 ± 3.21	42.56 ± 2.52^a
Palmatine for 10 days	0.1 mg	103.93 ± 2.95	100.93 ± 3.13	78.09 ± 4.01^b	44.22 ± 2.98
Palmatine for 10 days	0.5 mg	100 ± 3.25	88.38 ± 3.84	61.56 ± 2.98^c	32.09 ± 2.4^b
Palmatine for 10 days	1 mg	99.75 ± 2.80	75.43 ± 3.54^b	49.78 ± 2.31	26.06 ± 1.54^c
Palmatine for 10 days + scopolamine on 10th day	1 mg + 0.4 mg	107.29 ± 3.01	83.69 ± 3.48	54.75 ± 2.26	28.13 ± 1.33^d
Palmatine for 10 days + diazepam on 10th day	1 mg + 1 mg	109.90 ± 2.23	85.21 ± 2.84	55.81 ± 3.39	29.91 ± 1.59^e

𝑛=8. Values are expressed as Mean ± SEM. Data was analyzed by one-way ANOVA followed by Tukey’s post-hoc test.
𝐹(8, 279) = 1.264; 𝑃=0.2625 (day 6);
𝐹(8, 279) = 7.147; 𝑃<0.0001 (day 7);
𝐹(8, 279) = 11.079; 𝑃<0.0001 (day 8);
𝐹(8, 279) = 14.251; 𝑃<0.0001 (day 9);
^a𝑃<0.05 as compared to control;
^b𝑃<0.01 as compared to control;
^c𝑃<0.001 as compared to control;
^d𝑃<0.001 as compared to scopolamine treated group;
^e𝑃<0.01 as compared to diazepam treated group.