Figure 1: Representation of the GABAA receptor structure. The inhibitory GABAA receptor consists of five subunits that together form a ligand-gated chloride (Cl) channel (a). When GABA binds (between the α and the β subunit of the GABAA receptor), chloride ions flow into the neuron, resulting in a hyperpolarization of the cell membrane (a). Classical nonselective benzodiazepines allosterically enhance the inhibitory actions of GABA by binding between the α 1, α 2, α 3, or α 5 subunit and the γ subunit (b). Although the GABAA receptor displays a large molecular heterogeneity depending on the subunit composition, the most common subtype is a pentamer with 2α, 2β, and 1γ subunit.