Advances in Pharmacological and Pharmaceutical Sciences / 2012 / Article / Tab 1 / Research Article
Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats Table 1 Morphometric parameters and hemodynamic data of control and monocrotaline-injected male rats.
Control MCT-induced pulmonary hypertension groups. MSM (mg/kg/day) 0 100 200 400
Morphometric parameters Body wt (g) 265 ± 8 204 ± 12* 230 ± 10 244 ± 21 262 ± 11 0.39 <0.01 Heart (g) 0.71 ± 0.13 0.81 ± 0.19 0.78 ± 0.18 0.75 ± 0.20 0.74 ± 0.17 0.09 0.21 Heart/body wt (mg/g) 2.67 ± 0.11 3.4 ± 0.14** 3.44 ± 0.27 3.23 ± 0.53 2.84 ± 0.054 0.36 <0.01 RV wt (g) 0.16 ± 0.01 0.31 ± 0.04** 0.25 ± 0.02 0.22 ± 0.03 0.18 ± 0.01 0.38 <0.01 RV/body wt (mg/g) 0.59 ± 0.04 1.54 ± 0.15** 1.09 ± 0.15* 0.92 ± 0.27 0.70 ± 0.38 0.46 <0.01 LV + S wt (g) 0.55 ± 0.02 0.50 ± 0.01 0.53 ± 0.02 0.53 ± 0.01 0.56 ± 0.02 0.23 0.04 LV + S/body wt (mg/mg) 2.08 ± 0.08 2.46 ± 0.08 2.33 ± 0.15 2.24 ± 0.26 2.15 ± 0.07 0.15 0.11 RV/LV + S 0.28 ± 0.02 0.62 ± 0.07** 0.47 ± 0.04* 0.42 ± 0.06 0.33 ± 0.03 0.50 <0.01 Lung wet (g) 1.11 ± 0.06 3.09 ± 0.14** 2.23 ± 0.36* 1.99 ± 0.26 1.28 ± 0.09 0.60 <0.01 Lung dry (g) 0.25 ± 0.01 0.52 ± 0.02** 0.46 ± 0.06* 0.41 ± 0.06 0.27 ± 0.02 0.50 <0.01 Lung dry/wet 0.22 ± 0.03 0.17 ± 0.02** 0.20 ± 0.09 0.21 ± 0.03 0.21 ± 0.03 0.36 0.01 Lung wet/body wt (mg/g) 4.19 ± 0.18 15.17 ± 1.15** 9.35 ± 2.06* 8.17 ± 2.38 4.83 ± 0.20 0.60 <0.01 Hemodynamic data HR (beats/min) 397 ± 31 274 ± 19* 312 ± 16 326 ± 24 406 ± 31 0.47 <0.01 MAP (mmHg) 83.28 ± 7.42 54.07 ± 7.13** 53.100 ± 2.76** 58.68 ± 3.149* 77.83 ± 1.31 0.62 <0.01 RVSP (mmHg) 22.56 ± 1.65 35.87 ± 1.76** 29.21 ± 2.79 27.65 ± 2.60 22.62 ± 2.11 0.53 <0.01 RV
(mmHg/s) 1958 ± 40 2376 ± 116* 2196 ± 25 2130 ± 50 2027 ± 39 0.39 <0.01
(ms) 14.43 ± 0.92 22.62 ± 0.83** 19.05 ± 1.43* 17.44 ± 0.91 15.65 ± 0.97 0.53 <0.01
Data are mean ± SE. Significant Tukey's post hoc differences compared with controls are indicated by asterisks (**
and *
) and
is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; RV: right ventricle; LV: left ventricle; S: septum; wt: weight; HR: heart rate; MAP: mean arterial pressure; RVSP: right ventricular systolic pressure; RV
: peak rate of right ventricular pressure;
: relaxation time constant.
