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Advances in Pharmacological Sciences
Volume 2012 (2012), Article ID 768720, 16 pages
Research Article

Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair

1Avipero Ltd., 5th Floor, 125 Princes Street, Edinburgh EH2 4AD, UK
2School of Biomedical Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
3Division of Pathology, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
4MRC Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

Received 16 August 2011; Revised 21 October 2011; Accepted 31 October 2011

Academic Editor: Chi Hin Cho

Copyright © 2012 Rehab AlJamal-Naylor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Time lapse video of epithelial-mesenchymal cultures during stretch at 2–10% amplitude at 1 Hz for up to 6 hours (compressed videos) demonstrating the S1. Baseline formation of F-actin (blue) and caspase 3/7 activation (red, Sytox green was used for cell tracking) in control cultures, S2. The increase in formation of F-actin (blue) and caspase 3/7 activation (red) in response to elastase (PPE, 0.6 U/mL), and S3. The inhibition of the increase in F-actin (blue) and caspase 3/7 activation (red) in response to elastase (PPE, 0.6 U/mL) by targeting β1 integrin using JB1a (1 ug/mL).

  1. Supplementary Material 1
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  3. Supplementary Material 3