Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats

Table 1

Effect of curcumin on the severity of histopathological lesions in methotrexate- (MTX-) induced nephrotoxicity in rats.

Groups	Tubular degeneration	Tubular dilatation	Glomerular degeneration
Control	0	0	0
Curcumin	0	0	0
MTX	+++	+++	+
MTX + curcumin	+	+	0

Score level 0 was considered normal. Scores +, ++, and +++ are mild, moderate, and severe levels, revealing less than 25, 50 and 75% histopathological alterations of total fields examined, respectively. Score represents values obtained from tissue sections of 3 animals of each group.