Antimicrobial, Antioxidant, and Wound Healing Properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC.
Figure 10
Histopathological examination of wound tissues treated with vehicle, extracts, and the untreated tissues. Representative images stained with hematoxylin and eosin stain, Van Gieson’s stain and toluidine blue stain treated daily with 7.5% w/w creams of methanol leaf extract (KAL) of K. africana (a), methanol stem bark extract (KASB) of K. africana (b), methanol leaf extract (SHL) cream of S. hispidus (c) and methanol root extract (SHR) cream of S. hispidus (d) and the untreated wound tissues (e) for 14 days. (a) KAL: profuse angiogenesis, enhanced collagenation, and reepithelialization, evident of marked treatment responses amidst persistent inflammation. (b) KASB: appreciable angiogenesis and granulation tissue formation with evidence of apoptosis following tissue necrosis with less intense collagenation and reepithelialization. (c) SHL: With appreciable intense collagenation and reepithelialization. (d) SHR: With appreciable granulation tissue formation manifested as tissue refilling. Collagenation and re-epithelialization were also in earnest compared to the untreated wound tissue. (e) Untreated wound tissues with persistent inflammation with incomplete wound area; evidence of poor granulation tissue formation, collagenation and reepithelialization but profuse angiogenesis. (f) Treated wound tissues with 1% w/w silver sulphadiazine showed rapid granulation tissue formation, collagenation, evident of enhanced wound healing and uneven keratinous wound surface evident reepithelialization. Legend: AG: angiogenesis, CO: collagenation, DS: dead space following necrosis, GR: granulation tissue following apoptosis, IC: incomplete wound area, IF: inflamed tissue, KE: keratinous epithelium, ND: necrotic debris of persistent inflammation. RE: reepithelialisation.
