Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 4
Effects of orally administered E. speciosa on carbachol-induced gastric ulcers and gastric secretion in rats.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
4.03 ± 0.13
—
49.34 ± 3.20
6.89 ± 0.22
2.59 ± 0.04
84.80 ± 3.57
CH3OH/CH2Cl2
200
1.43 ± 0.37***
64.52
78.82 ± 3.64**
3.57 ± 0.30***
4.35 ± 0.12***
54.00 ± 4.30**
CH2Cl2 fraction
200
1.73 ± 0.50***
57.07
76.08 ± 2.83**
3.71 ± 0.25***
4.12 ± 0.14***
59.80 ± 4.49**
Aqueous extract
200
1.20 ± 0.34***
70.22
79.19 ± 3.66**
3.99 ± 0.27***
4.24 ± 0.22***
50.00 ± 4.26***
Cimetidine
50
1.10 ± 0.46***
72.71
69.42 ± 3.42*
2.76 ± 0.37***
5.48 ± 0.17***
39.00 ± 5.34***
N = 5 rats per treatment; *P < 0.05, statistically significant relative to control; **P < 0.01, statistically highly significant relative to control; ***P < 0.001, statistically very highly significant relative to control.
