Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 7
Effects of orally administered aqueous extract of E. speciosa on gastric ulceration and secretion in rats submitted to the augmented histamine test.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
4.33 ± 0.17
—
52.84 ± 2.42
7.42 ± 0.26
2.29 ± 0.06
90.20 ± 2.71
E. speciosa
200
2.27 ± 0.19***
47.58
82.20 ± 2.82***
3.76 ± 0.26***
3.99 ± 0.16***
52.60 ± 2.96***
E. speciosa
400
0.00 ± 0.0***
100.00
96.51 ± 3.12***
2.20 ± 0.27***
4.65 ± 0.10***
27.50 ± 1.29***
Ranitidine
100
0.00 ± 0.00***
100.00
73.21 ± 2.43***
2.06 ± 0.18***
5.02 ± 0.17***
19.20 ± 1.68***
N = 5 rats per treatment; ***P < 0.001; statistically very highly significant relative to control.
