Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitotoxicity

<table>Glutamate released from the synaptosomes at different time points detected fluorimetrically. Diazepam and phenobarbitone did not show any inhibition in the glutamate release. Glutamate release from the synaptosomes of the animals of sodium valproate group (T-3) group was significantly lower than the diseased control group [<svg height="11.225" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) from that of disease control animals.</table>

Advances in Pharmacological and Pharmaceutical Sciences

fig2

Figure 2

Figure 2: Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitotoxicity 

Figure 2 | Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitotoxicity 