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Advances in Pharmacological Sciences
Volume 2014 (2014), Article ID 820589, 4 pages
Research Article

Response of Bone Resorption Markers to Aristolochia longa Intake by Algerian Breast Cancer Postmenopausal Women

1Laboratory of Bioconversion, Microbial engineering and Health Safety, Department of Biology, University of Mascara, 29000 Mascara, Algeria
2Laboratory of Research on Biological Systems and Geomatics, University of Mascara, 29000 Mascara, Algeria

Received 27 January 2014; Accepted 10 April 2014; Published 30 April 2014

Academic Editor: Thérèse Di Paolo-Chênevert

Copyright © 2014 Bachir Benarba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aristolochia longa is widely used in traditional medicine in Algeria to treat breast cancer. The aim of the present study was to investigate the response of bone resorption markers to A. longa intake by Algerian breast cancer postmenopausal women. According to the A. longa intake, breast cancer patients were grouped into A. longa group (Al) and non-A. longa group (non-Al) . 32 women constituted the control group. Bone resorption markers (from urine) pyridinoline (PYD) and deoxypyridinoline (DPD) were determined by HPLC. Serum and urinary creatinine, uric acid, and urea were measured. 1 g of A. longa intake resulted in significant rise of renal serum markers and a pronounced increase of bone resorption markers. The intake of A. longa roots is detrimental for kidney function and resulted in high bone resorption, maybe due to the reduction in renal function caused by the aristolochic acids contained in the roots.