Advances in Pharmacological and Pharmaceutical Sciences / 2014 / Article / Tab 1

Research Article

Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells

Table 1

Cytotoxic activity of coumarins isolated from Prangos ferulacea against human cancer cell lines.

SKNMCPC3 H1299
IC50 (μM) MAE (%)IC50 (μM) MAE (%)IC50 (μM) MAE (%)

Osthole28.81 ± 0.7969.65 (5.93)20.1 ± 2.1 70.38 ± 2.658.43 ± 2.1552.18 ± 10.94
Isoimperatorin182 ± 10.91 63.38 ± (10.94)119.4 ± 8.6555.14 ± 1.7430013.89 ± 3.01
Oxypeucedanin 300103001030010
Braylin300103001030010

MAE: maximum antiprolifrative effect.