Simple and Robust Analysis of Cefuroxime in Human Plasma by LC-MS/MS: Application to a Bioequivalence Study

Table 3

Mean pharmacokinetic parameters for cefuroxime after oral administration of 500 mg of test and reference formulations to healthy human volunteers under fasting condition (𝑛=22).

Parameters (units)	Reference formulation; Mean ± SD	Test formulation; Mean ± SD	Point estimate; (90% Cls)
𝑇max (h)	2.14±0.85	2.25±0.95	—
𝐶max (𝜇g/mL)	6.42±1.19	6.31±1.45	97.6 (91.42–104.2)
𝑇1/2 (h)	1.33±0.10	1.38±0.16	—
AUC0--𝑡 (𝜇g·h/mL)	22.01±3.95	23.02±4.78	103.9 (97.4–110.9)
AUC0--∞ (𝜇g·h/mL)	22.30±4.00	23.36±4.87	104.1 (97.6–111.1)