Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice

Table 3

Histopathology scoring of tumor-bearing mice treated with 5-fluorouracil (20 mg/kg), spirulina (200 or 800 mg/kg), and their combination.

	Necrosis	Neovascularization	Leukocytes	Fibrosis
EAC	8–12%	+++	+	−
FU	50–60%	+	+++	++
SP200	10–15%	+++	++	−
SP800	10–15%	+++	++	−
FU/SP200	60–70%	+	+++	+++

EAC: Ehrlich ascites carcinoma tumor-bearing mice; FU: Ehrlich ascites carcinoma tumor-bearing mice treated with 5-fluorouracil (20 mg/kg); SP200: Ehrlich ascites carcinoma tumor-bearing mice treated with spirulina (200 mg/kg); SP800: Ehrlich ascites carcinoma tumor-bearing mice treated with spirulina (800 mg/kg); FU/SP200: Ehrlich ascites carcinoma tumor-bearing mice treated with 5-fluorouracil (20 mg/kg) plus spirulina (200 mg/kg). (−) none; (+) mild; (++) moderate; (+++) severe; (++++) more severe.