Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats

Table 1

Effects of lisinopril and fosinopril on the transfer latencies on 1st day and 2nd day in elevated plus maze test.

Treatment	Transfer latency on the; 1st day (sec)	Transfer latency on 2nd day; after 24 h (sec)
Control	57.50 ± 4.32	35.50 ± 2.15
Saline control	61.00 ± 3.20	37.90 ± 2.81
Scopolamine	92.17 ± 5.57^b	94.00 ± 3.55^b
Lisinopril (0.225 mg/kg) + scopolamine	83.33 ± 3.81^b	75.61 ± 2.75^b
Lisinopril (0.45 mg/kg) + scopolamine	76.16 ± 5.74	55.17 ± 3.04
Fosinopril (0.90 mg/kg) + scopolamine	85.33 ± 3.56^b	75.67 ± 5.16^b
Fosinopril (1.80 mg/kg) + scopolamine	73.50 ± 3.34	53.00 ± 3.67

Comparisons between control, scopolamine, lisinopril, and fosinopril treated groups in the elevated plus maze test. Values are mean ± SE, versus scopolamine (), versus scopolamine (), ^aversus control (), and ^bversus control ().