Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats

Table 5

Effects of lisinopril and fosinopril in the probe trial on day 5 of Morris water maze test.

Treatment	Latency to enter the target quadrant (sec)	Total time spent in target quadrant (sec)
Control	14.59 ± 1.54	26.11 ± 0.54
Saline control	17.11 ± 1.62	29.20 ± 1.66
Scopolamine	27.48 ± 2.00^b	12.58 ± 0.42^b
Lisinopril (0.225 mg/kg) + scopolamine	23.90 ± 1.37^b	12.28 ± 0.37^b
Lisinopril (0.45 mg/kg) + scopolamine	22.83 ± 1.96^b	14.75 ± 0.96^b
Fosinopril (0.90 mg/kg) + scopolamine	22.29 ± 1.91^b	14.37 ± 0.91^b
Fosinopril (1.80 mg/kg) + scopolamine	20.18 ± 0.85	19.25 ± 1.85

Comparison between control, scopolamine, lisinopril, and fosinopril treated groups in the probe trial of Morris water maze test in which no platform was present. Values are mean ± SE, versus scopolamine (), versus scopolamine (), versus control (), and versus control ().