Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies

Figure 2

Clinical outcome after treatment with topical 5,3′-hydroxy-7,4′-dimethoxyflavanone isolated from P. gracilis Tul. fruit. Bars represent the mean value ± SD of clinical outcome in arbitrary units scored at the end of the treatment (a), PTD30 (b), PTD60 (c), and PTD90 (d). Axis : group treated with flavanone solution (group A); group treated with 2% flavanone cream (group B); and group treated with trademark meglumine antimoniate (group C). Axis : score of 0 = failure; 1 = relapse; 2 = clinical improvement; and 3 = cure.

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