Advances in Pharmacological and Pharmaceutical Sciences / 2015 / Article / Tab 1

Research Article

Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies

Table 1

In vitro cytotoxicity and antileishmanial activity of Picramnia gracilis Tul.

ProductBiological activity (μg/mL)IS
LC50EC50

E-EtOH-le>200.0>100.0>2
E-He-le22.4 ± 5.4>22.4<1
E-DiCl-Me-le29.1 ± 9.0>29.1<1
E-EtAc-le>200.0>100.0>2
E-EtOH-fr>200.035.7 ± 1.3>2
5,3-Hydroxy-7,4-dimethoxyflavanone>200.017.0 ± 2.8 (53.7 μM)>11.8
Amphotericin B37.5 ± 7.60.06 ± 0.004625.0
Meglumine antimoniate>1000.06.8 + 0.5>147.1

Data represent the mean value ± SD of cytotoxicity in terms of 50% lethal concentration (LC50) and leishmanicidal activity in terms of 50% effective concentration (EC50). E-EtOH-fr: ethanolic extract from fruit; E-EtOH-le: ethanolic extract from leaves; E-DiClMe-le: dichloromethane extract from leaves; E-He-le: hexane extract from leaves; and E-EtAc-le: ethyl acetate extract from leaves. IS (index of selectivity) = LC50/EC50.

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