Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 4

Effect of naproxen metal complexes on phenobarbitone sodium-induced sleep.

Group	Dose (mg/kg)	Parameters observed
		Time of onset of sleep (min)	Total sleeping time (min)	Duration of sleep (min)
Control	—	16.67 ± 0.71	137.17 ± 1.7	120.50 ± 1.8
Naproxen	25	13.83 ± 0.60	157.17 ± 3.6	143.33 ± 3.7
Naproxen-copper complex	25	15.00 ± 0.85	172.00 ± 3.1	157.00 ± 3.7
Naproxen-cobalt complex	25	14.00 ± 0.60	154.17 ± 2.7	140.17 ± 3.2
Naproxen-iron complex	25	14.00 ± 0.96	153.83 ± 2.1	139.83 ± 2.1
Naproxen-silver complex	25	15.17 ± 1.2	138.00 ± 2.6	122.83 ± 3.6
Naproxen-zinc complex	25	13.33 ± 0.49	153.50 ± 2.5	140.17 ± 2.1
Diazepam	1	4.80 ± 0.37	186.80 ± 2.5	182.00 ± 3.11

Each value represents the mean ± SEM (). and compared with control.