Advances in Pharmacological and Pharmaceutical Sciences / 2016 / Article / Tab 4

Research Article

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 4

Effect of naproxen metal complexes on phenobarbitone sodium-induced sleep.

GroupDose (mg/kg)Parameters observed
Time of onset of sleep (min)Total sleeping time (min)Duration of sleep (min)

Control16.67 ± 0.71137.17 ± 1.7120.50 ± 1.8
Naproxen2513.83 ± 0.60157.17 ± 3.6143.33 ± 3.7
Naproxen-copper complex2515.00 ± 0.85172.00 ± 3.1157.00 ± 3.7
Naproxen-cobalt complex2514.00 ± 0.60154.17 ± 2.7140.17 ± 3.2
Naproxen-iron complex2514.00 ± 0.96153.83 ± 2.1139.83 ± 2.1
Naproxen-silver complex2515.17 ± 1.2138.00 ± 2.6122.83 ± 3.6
Naproxen-zinc complex2513.33 ± 0.49153.50 ± 2.5140.17 ± 2.1
Diazepam1 4.80 ± 0.37186.80 ± 2.5182.00 ± 3.11

Each value represents the mean ± SEM (). and compared with control.

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