Research Article
Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties
Table 5
Effect of naproxen metal complexes on hypoglycemic property in mice.
| | Group | Dose (mg/kg) | Plasma glucose level in mmol/L | | 0 hours | 1st hour | 2nd hour | 3rd hour |
| | Control | — | 5.98 ± 0.28 | 6 ± 0.15 | 5.9 ± 0.19 | 5.75 ± 0.17 | | Standard | 50 | 6.05 ± 0.18 | 3.78 ± 0.13 | 3.6 ± 0.15 | 3.43 ± 0.11 | | Naproxen | 25 | 5.72 ± 0.27 | 5.78 ± 0.15 | 5.58 ± 0.10 | 5.73 ± 0.19 | | Naproxen-copper complex | 25 | 6.15 ± 0.19 | 4.37 ± 0.19 | 4.3 ± 0.05 | 4.72 ± 0.13 | | Naproxen-cobalt complex | 25 | 5.73 ± 0.18 | 4.7 ± 0.17 | 4.5 ± 0.10 | 4.6 ± 0.14 | | Naproxen-iron complex | 25 | 5.78 ± 0.22 | 5.58 ± 0.24 | 5.65 ± 0.20 | 5.7 ± 0.19 | | Naproxen-silver complex | 25 | 5.8 ± 0.24 | 6.03 ± 0.13 | 5.82 ± 0.12 | 5.72 ± 0.18 | | Naproxen-zinc complex | 25 | 5.22 ± 0.22 | 4.53 ± 0.18 | 4.17 ± 0.17 | 4.17 ± 0.14 |
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Each value represents the mean ± SEM, . was considered significant compared with control.
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