Advances in Pharmacological and Pharmaceutical Sciences / 2016 / Article / Tab 5

Research Article

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 5

Effect of naproxen metal complexes on hypoglycemic property in mice.

GroupDose (mg/kg)Plasma glucose level in mmol/L
0 hours1st hour2nd hour3rd hour

Control5.98 ± 0.286 ± 0.155.9 ± 0.195.75 ± 0.17
Standard 506.05 ± 0.183.78 ± 0.133.6 ± 0.153.43 ± 0.11
Naproxen255.72 ± 0.275.78 ± 0.155.58 ± 0.105.73 ± 0.19
Naproxen-copper complex256.15 ± 0.194.37 ± 0.194.3 ± 0.054.72 ± 0.13
Naproxen-cobalt complex255.73 ± 0.184.7 ± 0.174.5 ± 0.104.6 ± 0.14
Naproxen-iron complex255.78 ± 0.225.58 ± 0.245.65 ± 0.205.7 ± 0.19
Naproxen-silver complex255.8 ± 0.246.03 ± 0.135.82 ± 0.125.72 ± 0.18
Naproxen-zinc complex255.22 ± 0.224.53 ± 0.184.17 ± 0.174.17 ± 0.14

Each value represents the mean ± SEM, .   was considered significant compared with control.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.